A Prospective Study on Cellulitis in Adult Patients with Analysis of the Factors Related to the Response to Treatment
Keywords:
Cellulitis, treatment response, predictors, microbiological, logistic regression, imaging studiesAbstract
Background- The hallmarks of cellulitis include heated, red, and swollen purulent or non-purulent skin patches that can develop into more serious issues like sepsis and lymphedema. Cellulitis can strike anyone at any age, but it is more frequent in middle-aged and older people, with a small male preponderance.
Objectives- The goal of this research is to clarify the many factors that affect how well cellulitis treatments work.
Materials and Methods- Patients with cellulitis diagnosed between May 2022 and April 2023 were the subjects of this prospective observational study, which was carried out at the Department of General Surgery, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, India. The study included 100 individuals in total.
Results- People under 65 made up the majority of the study population (65%), with the remaining 35 (35%) being 65 or older. There were 45 (45%) female participants and 55 (55%), male volunteers, making up the slight majority. Ninety-eight percent, or 98 people, were Indian. The logistic regression model's effectiveness in categorizing the treatment response is shown by the Receiver Operating Characteristic (ROC) Curve above.
Conclusion- The significance of a thorough strategy that takes into account patient demographics, co-morbidities, clinical characteristics, microbiological variables, and imaging results when customizing treatment for cellulitis is highlighted by this study. It emphasizes how important focused interventions are to enhancing treatment results, particularly for high-risk patients.
References
Falcone M, Meier JJ, Marini MG, Caccialanza R, Aguado JM, Del Prato S, Menichetti F. Diabetes and acute bacterial skin and skin structure infections. Diabetes research and clinical practice. 2021 Apr 1;174:108732.
Miller KM, Lamagni T, Hay R, Cannon JW, Marks M, Bowen AC, Kaslow DC, Cherian T, Seale AC, Pickering J, Daw JN. Standardization of epidemiological surveillance of group A Streptococcal cellulitis. InOpen forum infectious diseases 2022 Sep 15 (Vol. 9, No. Supplement_1, pp. S25-S30). US: Oxford University Press.
Abramowicz S, Rampa S, Allareddy V, Lee MK. The burden of facial cellulitis leading to inpatient hospitalization. Journal of Oral and Maxillofacial Surgery. 2017 Aug 1;75(8):1656-67.
Marcelin JR, Challener DW, Tan EM, Lahr BD, Baddour LM. Incidence and effects of seasonality on nonpurulent lower extremity cellulitis after the emergence of community-acquired methicillin-resistant Staphylococcus aureus. InMayo Clinic Proceedings 2017 Aug 1 (Vol. 92, No. 8, pp. 1227-1233). Elsevier.
Dupuy A, Benchikhi H, Roujeau JC, Bernard P, Vaillant L, Chosidow O, Sassolas B, Guillaume JC, Grob JJ, Bastuji-Garin S. Risk factors for erysipelas of the leg (cellulitis): case-control study. Bmj. 1999 Jun 12;318(7198):1591-4.
Björnsdóttir S, Gottfredsson M, Thórisdóttir AS, Gunnarsson GB, Ríkardsdóttir H, Kristjánsson M, Hilmarsdóttir I. Risk factors for acute cellulitis of the lower limb: a prospective case-control study. Clinical infectious diseases. 2005 Nov 15;41(10):1416-22.
Cannon J, Dyer J, Carapetis J, Manning L. Epidemiology and risk factors for recurrent severe lower limb cellulitis: a longitudinal cohort study. Clinical Microbiology and Infection. 2018 Oct 1;24(10):1084-8.
Collazos J, de la Fuente B, García A, Gómez H, Menéndez C, Enríquez H, Sánchez P, Alonso M, López-Cruz I, Martín-Regidor M, Martínez-Alonso A. Cellulitis in adult patients: a large, multicenter, observational, prospective study of 606 episodes and analysis of the factors related to the response to treatment. PLOS ONE. 2018 Sep 27;13(9):e0204036.
Chen KC, Lin AC, Chong CF, Wang TL. An overview of point-of-care ultrasound for soft tissue and musculoskeletal applications in the emergency department. Journal of Intensive Care. 2016 Dec;4:1-1.
Ortiz-Lazo E, Arriagada-Egnen C, Poehls C, Concha-Rogazy M. An update on the treatment and management of cellulitis. Actas Dermo-Sifiliográficas (English Edition). 2019 Mar 1;110(2):124-30.
Peterson D, McLeod S, Woolfrey K, McRae A. Predictors of failure of empiric outpatient antibiotic therapy in emergency department patients with uncomplicated cellulitis. Academic Emergency Medicine. 2014 May;21(5):526-31.
Dong SL, Kelly KD, Oland RC, Holroyd BR, Rowe BH. ED management of cellulitis: a review of five urban centers. The American journal of emergency medicine. 2001 Nov 1;19(7):535-40.
Labreche MJ, Lee GC, Attridge RT, Mortensen EM, Koeller J, Du LC, Nyren NR, Treviño LB, Treviño SB, Peña J, Mann MW. Treatment failure and costs in patients with methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections: a South Texas Ambulatory Research Network (STARNet) study. The Journal of the American Board of Family Medicine. 2013 Sep 1;26(5):508-17.
Murray H, Stiell I, Wells G. Treatment failure in emergency department patients with cellulitis. Canadian Journal of Emergency Medicine. 2005 Jul;7(4):228-34.
Miller LG, Daum RS, Creech CB, Young D, Downing MD, Eells SJ, Pettibone S, Hoagland RJ, Chambers HF. Clindamycin versus trimethoprim–sulfamethoxazole for uncomplicated skin infections. New England Journal of Medicine. 2015 Mar 19;372(12):1093-103.
Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clinical infectious diseases. 2014 Jul 15;59(2):e10-52.
Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: a review of their epidemiology, pathogenesis, diagnosis, treatment, and site of care. Canadian Journal of Infectious Diseases and Medical Microbiology. 2008;19(2):173-84.
Quirke M, Ayoub F, McCabe A, Boland F, Smith B, O'Sullivan R, Wakai A. Risk factors for nonpurulent leg cellulitis: a systematic review and meta‐analysis. British journal of dermatology. 2017 Aug 1;177(2):382-94.
Suaya JA, Eisenberg DF, Fang C, Miller LG. Skin and soft tissue infections and associated complications among commercially insured patients aged 0–64 years with and without diabetes in the US. PLoS One. 2013 Apr 10;8(4):e60057.
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Mukesh Kumar, Vivek Kumar Roy, Swati Priya, Anand Dev, Krishna Gopal, Nidhi Arun

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.