Comparative outcomes of holmium laser En bloc resection in superficial bladder tumors: Focus on operative time, catheterization, and hospital stay- A cross-sectional study.
DOI:
https://doi.org/10.51168/sjhrafrica.v6i6.1873Keywords:
Tumor, Bladder, TURBT, Holmium Laser, Outcomes, Transurethral resection of the bladder tumorAbstract
Background
In 2016, bladder cancer accounted for 186,000 fatalities and 437,000 new cases, making it the tenth most frequent cancer worldwide. The incidence of bladder urothelial carcinoma varies greatly by geography, with Eastern Europe and Asian nations having the lowest rates and Western Europe and North America having the greatest frequency.
Objectives- The purpose of the study was to evaluate the results of holmium laser En Bloc resection for superficial bladder cancers.
Materials and methods
It was a cross-sectional, observational study. The study was carried out in the Department of Urology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India. The study was conducted for one and a half years, that is, from December 2021 to Jun 2023. In all, 24 patients were enrolled. Patients over the age of 18 with superficial bladder cancer who intend to have their bladder tumors removed by transurethral resection (TURBT) at the Mahatma Gandhi Medical College and Research Institute in Puducherry within six months of receiving approval from the institutional ethics committee are included in this study.
Results
Nine patients (37.5%) had tumors in the right lateral bladder wall, while six patients (25%) had tumors in the posterior wall. Patients with multiple lesions used a larger median number of analgesic vials after surgery (2.00; IQR: 2.00–3.00) than patients with single lesions (1.00; IQR: 1.00–2.00). With a p-value of 0.017, this difference was statistically significant.
Conclusion
For the treatment of superficial bladder cancers, holmium laser en bloc excision is a secure and efficient method. In patients with single lesions, the method was linked to significantly lower analgesic requirements, shorter catheterization and hospital stays, and acceptable operative timeframes.
Recommendations
Further research, including larger-scale studies, is necessary to validate these observations and enhance the understanding of TURBT procedures' efficacy and safety.
References
Ebrahimi H, Amini E, Pishgar F, Moghaddam SS, Nabavizadeh B, Rostamabadi Y, Aminorroaya A, Fitzmaurice C, Farzadfar F, Nowroozi MR, Black PC. Global, regional, and national burden of bladder cancer, 1990 to 2016: results from the GBD study 2016. The Journal of Urology. 2019 May;201(5):893-901. https://doi.org/10.1097/JU.0000000000000025 PMid:30676477
Pelucchi C, Bosetti C, Negri E, Malvezzi M, La Vecchia C. Mechanisms of disease: the epidemiology of bladder cancer. Nature Clinical Practice Urology. 2006 Jun 1;3(6):327-40. https://doi.org/10.1038/ncpuro0510 PMid:16763645
Michaud DS, Clinton SK, Rimm EB, Willett WC, Giovannucci E. Risk of bladder cancer by geographic region in a US cohort of male health professionals. Epidemiology. 2001 Nov 1;12(6):719-26. https://doi.org/10.1097/00001648-200111000-00022 PMid:11679802
Schulz MR, Loomis D. Occupational bladder cancer mortality among racial and ethnic minorities in 21 states. American journal of industrial medicine. 2000 Jul;38(1):90-8. https://doi.org/10.1002/1097-0274(200007)38:1<90::AID-AJIM10>3.0.CO;2-Q PMid:10861770
Burger M, Catto JW, Dalbagni G, Grossman HB, Herr H, Karakiewicz P, Kassouf W, Kiemeney LA, La Vecchia C, Shariat S, Lotan Y. Epidemiology and risk factors of urothelial bladder cancer. European Urology. 2013 Feb 1;63(2):234-41. https://doi.org/10.1016/j.eururo.2012.07.033 PMid:22877502
Lynch CF, Cohen MB. Urinary system. Cancer. 1995 Jan 1;75(S1):316-29. https://doi.org/10.1002/1097-0142(19950101)75:1+<316::AID-CNCR2820751314>3.0.CO;2-T PMid:8001003
Hinotsu S, Akaza H, Miki T, Fujimoto H, Shinohara N, Kikuchi E, Mizutani Y, Koga H, Okajima E, Okuyama A, Japanese Urological Association. Bladder cancer develops 6 years earlier in current smokers: analysis of bladder cancer registry data collected by the Cancer Registration Committee of the Japanese Urological Association. International journal of urology. 2009 Jan;16(1):64-9. https://doi.org/10.1111/j.1442-2042.2008.02194.x PMid:19054170
Freedman ND, Abnet CC, Caporaso NE, Fraumeni Jr JF, Murphy G, Hartge P, Hollenbeck AR, Park Y, Shiels MS, Silverman DT. Impact of changing US cigarette smoking patterns on incident cancer: risks of 20 smoking-related cancers among the women and men of the NIH-AARP cohort. International journal of epidemiology. 2016 Jun 1;45(3):846-56. https://doi.org/10.1093/ije/dyv175 PMid:26411408 PMCid:PMC5005940
Linn JF, Sesterhenn I, Mostofi FK, Schoenberg M. The molecular characteristics of bladder cancer in young patients. The Journal of Urology. 1998 May 1;159(5):1493-6.https://doi.org/10.1097/00005392-199805000-00022 PMid:9554340
Nath G, Gorisch W, Kiefhaber P. First laser endoscopy via a fiber-optic transmission system. Endoscopy. 1973 Dec;5(04):208-13. https://doi.org/10.1055/s-0028-1098243
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BW. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016. European Urology. 2017 Mar 1;71(3):447-61. https://doi.org/10.1016/j.eururo.2016.05.041 PMid:27324428
Lu J, Xue Y, Shen F, Gu H, Liu H, Hou J, Miao H. Transurethral holmium laser resection and transurethral electrocision combined with intravesical epirubicin within 24 hours postoperatively for treatment of bladder cancer. Journal of International Medical Research. 2020 Jun;48(6):0300060519887267. https://doi.org/10.1177/0300060519887267 PMid:31885339 PMCid:PMC7309393
Huang JH, Hu YY, Liu M, Wang GC, Peng B, Yao XD. Comparative study of 2 μm laser versus Holmium laser for the resection of non-muscle invasive bladder cancer. Int J Clin Exp Med. 2016 Jan 1;9(12):23618-23.
Razzaghi MR, Mazloomfard MM, Yavar M, Malekian S, Mousapour P. Holmium LASER in comparison with transurethral resection of the bladder tumor for non-muscle invasive bladder cancer: randomized clinical trial with 18-month follow-up. Urology Journal. 2021 Jan 1;18(04):460-5.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Thota Siddhartha, Suvit Jumde

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.