A STUDY OF LIVER FUNCTION TESTS DERANGEMENTS IN LEPTOSPIROSIS IN A TERTIARY HEALTH CARE CENTER IN ODISHA: A COHORT STUDY.

Bikash Chandra  Nanda; Manoranjan  Naik; Balaram  Khamari

doi:10.51168/sjhrafrica.v6i3.1659

Authors

Bikash Chandra Nanda Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India
Manoranjan Naik Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India
Balaram Khamari Senior Resident, Department of General Medicine, VIMSAR, Burla, Odisha, India

DOI:

https://doi.org/10.51168/sjhrafrica.v6i3.1659

Keywords:

Liver Function Test (LFT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Leptospirosis, Duration of Hospital Stay

Abstract

Background

A zoonotic illness that is found throughout the world is leptospirosis. For growth, leptospires need specific media and circumstances. Positive cultural shifts might occur over weeks or months. Clinical, diagnostic, and epidemiologic objectives are best served by classifications based on serologic distinctions.

Objectives

This study aims to determine the distribution of leptospirosis patients by identifying the correlation between clinical factors at admission and six weeks later in leptospirosis patients.

Materials and Methods

The study was observational and prospective. The study was conducted in Burla, Sambalpur, Odisha, India, at the Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR). The research was conducted between February 2024 and January 2025. One hundred patients in all were enrolled in the trial.

Results

A total of 100 IgM lepto-antibody-positive patients were enrolled and completed the 6-week follow-up. The mean age was 42.3 ± 13.8 years, with 61% males and 39% females. Fever and myalgia were present in all patients, with other common symptoms including headache (75%) and icterus (68%). Liver function parameters such as AST, ALT, bilirubin, ALP, total protein, and albumin showed significant improvement after 6 weeks (p < 0.001). These results indicate notable hepatic recovery in leptospirosis patients.

Conclusion

The study came to the conclusion that elevated levels of bilirubin and transaminases were the primary way that the liver was involved in leptospirosis. Patients' bilirubin, AST, and ALT levels were much lower at 6 weeks than they were at admission.

Recommendation

Early diagnosis and regular monitoring of liver function are essential for effective management of leptospirosis. Public health strategies should focus on awareness and timely intervention to prevent hepatic complications.

Author Biographies

Bikash Chandra Nanda, Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India

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Manoranjan Naik, Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India

, (

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