A prospective comparative interventional study of diclofenac gel plus ormeloxifene versus diclofenac gel plus evening primrose oil in the treatment of mastalgia in benign breast diseases.
DOI:
https://doi.org/10.51168/sjhrafrica.v6i6.1885Keywords:
Mastalgia, Benign Breast Disease, Diclofenac Gel, Ormeloxifene, Evening Primrose OilAbstract
Background
Mastalgia, a common symptom of benign breast diseases, affects women's quality of life. This study aimed to compare the efficacy of diclofenac gel plus ormeloxifene versus diclofenac gel plus evening primrose oil in the treatment of mastalgia in benign breast diseases.
Methods
The study analyzed 100 female patients aged 18-45 with mastalgia in the Department of General Surgery at BRD Medical College, Gorakhpur, between 2023 and 2024. The patients were divided into two groups: Group A (diclofenac gel + ormeloxifene 30 mg twice weekly for 3 months) and Group B (diclofenac gel + evening primrose oil 1000 mg twice daily for 3 months).
Results
At baseline, both groups had comparable VAS scores (6.76 ± 1.45 in Group A vs. 6.40 ± 1.64 in Group B, p = 0.248). At 1 month, VAS scores decreased in both groups (4.30 ± 1.47 in Group A vs. 4.70 ± 1.66 in Group B, p = 0.205), with no significant difference. However, at 3 months, the VAS score reduction was significantly greater in Group A (1.36 ± 1.74) compared to Group B (2.84 ± 2.05) (p < 0.001), indicating superior pain relief with ormeloxifene. Intra-group analysis showed a significant reduction in pain over time in both groups (p < 0.001). A higher proportion of participants in Group A (76.00%) showed significant improvement compared to 40.00% in Group B (p = 0.001).
Conclusion
Ormeloxifene, when combined with diclofenac gel, demonstrated superior efficacy in reducing mastalgia symptoms compared to evening primrose oil, indicating its superior treatment option for benign breast diseases.
Recommendation
It recommends individualized treatment based on symptom severity, patient preference, and tolerance. Regular follow-up is recommended for pain relief, adherence, and side effects. Further large-scale studies are needed for validation and standardized treatment protocols.
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