A study of the prevalence and evaluation of metabolic syndrome in reproductive age women with polycystic ovarian syndrome –  A cross-sectional study.

Ipsita  Praharaj; Bhabani Shankar  Nayak; Sujata  Misra

doi:10.51168/sjhrafrica.v6i6.1909

Authors

Ipsita Praharaj Post graduate, Department of Obstetrics & Gynecology, PGIMER and Capital Hospital, Bhubaneswar, India
Bhabani Shankar Nayak Associate Professor, Department of Obstetrics & Gynecology, PGIMER and Capital Hospital, Bhubaneswar, India
Sujata Misra Professor, Department of Obstetrics & Gynecology, PGIMER and Capital Hospital, Bhubaneswar, India

DOI:

https://doi.org/10.51168/sjhrafrica.v6i6.1909

Keywords:

PCOS, Metabolic Syndrome, Obesity, Waist Circumference, High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL)

Abstract

Background

Polycystic Ovarian Syndrome (PCOS) is a multisystem endocrinopathy predominantly affecting women of reproductive age. It is frequently associated with metabolic abnormalities and carries a high risk of developing diabetes, cardiovascular disorders, and infertility if left unmanaged.

Methods

A cross-sectional study was conducted on a total of 200 PCOS women in the Obstetrics & Gynecology Department of PGIMER and Capital Hospital, Bhubaneswar. Detailed history, anthropometric measurements, and biochemical investigations were performed. The data were subsequently analysed using appropriate statistical methods.

Results

The incidence rates of metabolic syndrome in PCOS women were 34.5% showing an increasing trend with increasing age and obesity. Women with metabolic syndrome had significantly higher weight, BMI, waist circumference, triglycerides, LDL, and fasting glucose, and lower HDL than those without. Waist circumference (92%) and HDL (95%) were the most sensitive indicators of metabolic abnormalities. LDL (100%) and triglycerides (96%) were highly specific in identifying metabolic syndrome in PCOS.

Conclusion

The study highlights a strong association between obesity, unfavourable metabolic abnormalities, and PCOS. Waist circumference and HDL can serve as useful, non-invasive indicators for identifying metabolic syndrome in women with PCOS.

Recommendation

Future studies should include larger, diverse samples, longitudinal follow-up, hormonal profiling, lifestyle factors, and intervention-based assessments to strengthen findings.

References

Stener-Victorin E, Teede H, Norman RJ, Legro R, Goodarzi MO, Dokras A, Laven J, Hoeger K, Piltonen TT. Polycystic ovary syndrome. Nature Reviews Disease Primers. 2024 Apr 18;10(1):27. https://doi.org/10.1038/s41572-024-00511-3 PMid:38637590

Salari N, Nankali A, Ghanbari A, Jafarpour S, Ghasemi H, Dokaneheifard S, Mohammadi M. Global prevalence of polycystic ovary syndrome in women worldwide: a comprehensive systematic review and meta-analysis. Archives of gynecology and obstetrics. 2024 Sep;310(3):1303-14. https://doi.org/10.1007/s00404-024-07607-x PMid:38922413

Teede HJ, Hutchison S, Zoungas S, Meyer C. Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS. Endocrine. 2006 Aug;30:45-53. https://doi.org/10.1385/ENDO:30:1:45 PMid:17185791

Jeanes YM, Reeves S. Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges. Nutrition research reviews. 2017 Jun;30(1):97-105. https://doi.org/10.1017/S0954422416000287 PMid:28222828

Martin Velez L, Beatriz Motta A. Association between polycystic ovary syndrome and metabolic syndrome. Current medicinal chemistry. 2014 Nov 1;21(35):3999-4012. https://doi.org/10.2174/0929867321666140915141030 PMid:25245380

Carmina E. Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome. Polycystic Ovary Syndrome: Novel Insights Into Causes And Therapy. 2012 Oct 19;40:40-50. https://doi.org/10.1159/000341840 PMid:24002404

Afrand M, Afkhami-Ardekani M, Shojaoddiny-Ardekani A, Ariaeinejad A. Metabolic syndrome and ethnic groups. Knowledge Kingdom Publishing; 2021 Jan 18. https://doi.org/10.26415/978-9931-9446-4-5 PMid:35592836 PMCid: PMC8285244

Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS. Clinical characteristics of polycystic ovary syndrome in Indian women. Indian journal of endocrinology and metabolism. 2013 Jan 1;17(1):138-45. https://doi.org/10.4103/2230-8210.107858 PMid:23776867 PMCid: PMC3659881

Alaknanda et al. Dr Alakananda, Dr Bishnu Prasad Das, Dr Ishaa Goel, A Study on Clinical Profile of Patients with Polycystic Ovarian Syndrome. International Journal of Science and Research (IJSR). October 2017, 6 (10).

Kalra A, Nair S, Rai L. Association of obesity and insulin resistance with dyslipidemia in Indian women with polycystic ovarian syndrome. Indian J Med Sci. 2006; 60:447-53. https://doi.org/10.4103/0019-5359.27971 PMid:17090865

Radwan AM et al. Evaluation of different biochemical markers in prediction of metabolic syndrome in polycystic ovary syndrome patients. Int J Reprod Contracept Obstet Gynecol. 2017 Jul;6(7):2734-2740. https://doi.org/10.18203/2320-1770.ijrcog20172554

Mandrelle K, Karmath Metabolic syndrome, Bondu DJ, Chandy A, Aleyamma TK, George K. Prevalance of metabolic. Syndrome in women with PCOS attending an infertility clinic in a tertiary care hospital in South India. J Hum Reprod Sci. 2012; 5:26-31. https://doi.org/10.4103/0974-1208.97791 PMid:22870011 PMCid: PMC3409916

Ebrahimi-Mamaghani M, Saghafi-Asl M, Pirouzpanah S, et al. Association of insulin resistance with lipid profile, metabolic syndrome, and hormonal aberrations in overweight or obese women with polycystic ovary syndrome. J Health Popul Nutr. 2015;33(1):157-167.

Sidra S, Tariq MH, Farrukh MJ, Mohsin M. Evaluation of clinical manifestations, health risks, and quality of life among women with polycystic ovary syndrome. PLoS One. 2019 Oct 11;14(10):e0223329. doi: 10.1371/journal.pone.0223329. PMID: 31603907; PMCID: PMC6788722.