Blood culture correlation and antibiotic susceptibility profile of Acinetobacter species isolated from meningitis patients: a retrospective record-based study from a tertiary care centre in Delhi.

Sadia  Jabeen; Sarjana  Shuchi; Samit  Sen; Satija; Yogita Rai; Manoj B.   Jais

doi:10.51168/sjhrafrica.v6i12.2345

Authors

Sadia Jabeen Senior Resident, Department of Microbiology, Lady Hardinge Medical College, New Delhi, India
Sarjana Shuchi Senior Resident, Department of Microbiology, Lady Hardinge Medical College, New Delhi, India
Samit Sen Senior Resident, Department of Microbiology, Lady Hardinge Medical College, New Delhi, India
Shweta Satija Professor, Department of Microbiology, Lady Hardinge Medical College, New 4Shweta Delhi,
Yogita Rai Professor, Department of Microbiology, Lady Hardinge Medical College, New Delhi, India
Manoj B. Jais Director Professor & Head of the Department, Department of Microbiology, Lady Hardinge Medical College, New Delhi, India

DOI:

https://doi.org/10.51168/sjhrafrica.v6i12.2345

Keywords:

Acinetobacter meningitis, Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), Hypericum aethiopicum, MRSA, wound infections, antimicrobial resistance, phytochemical analysis., A. baumannii, multidrug resistance, colistin sensitivity

Abstract

Background:
Acinetobacter species, particularly A. baumannii, have emerged as important causes of hospital-acquired meningitis, especially among critically ill and pediatric patients. Increasing antimicrobial resistance among these organisms has become a major therapeutic challenge.

Aim:
To determine the prevalence of Acinetobacter species isolated from cerebrospinal fluid (CSF) and blood cultures of meningitis patients and to evaluate their antimicrobial susceptibility profile.

Methods:
A retrospective record-based study was conducted in the Department of Microbiology, Lady Hardinge Medical College, New Delhi, over a 12-month period (01 January 2023 to 31 December 2023). Data from 44 patients clinically suspected of meningitis were analysed. CSF and blood samples were cultured and isolates identified using standard microbiological techniques. Antimicrobial susceptibility testing was performed using the Kirby–Bauer disk diffusion method according to CLSI guidelines.

Results:
Among the 44 patients studied, Acinetobacter species were predominantly isolated from patients admitted to intensive care units and pediatric wards. A. baumannii was the most common species identified. CSF culture positivity was higher compared to blood culture positivity. Antimicrobial susceptibility testing showed high resistance to third-generation cephalosporins and carbapenems, while moderate susceptibility was observed with aminoglycosides and colistin. Similar resistance patterns were observed in isolates recovered from patients with both CSF and blood culture positivity.

Conclusion:
The study demonstrates the increasing prevalence of multidrug-resistant Acinetobacter infections in meningitis patients in tertiary care settings, highlighting the need for continuous antimicrobial surveillance and strict infection control measures

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